In Los Angeles, the eleven year old Anna Fitzgerald (Abigail Breslin) seeks the successful lawyer Campbell Alexander (Alec Baldwin) trying to hire him to earn medical emancipation from her mother Sara (Cameron Diaz) that wants Anna to donate her kidney to her sister. She tells the lawyer the story of her family after the discovery that her older sister Kate (Sofia Vassilieva) has had leukemia; how she was conceived by in vitro fertilization to become a donor; and the medical procedures she has been submitted since she was five years old to donate to her sister. Campbell accepts to work pro bono and the obsessed Sara decides to go to court to force Anna to help her sister.

"My Sister's Keeper" has a potential story with a promising beginning. However, the screenplay entwines flashback of situations of Kate's cancer sometimes in a confused way and has a melodramatic conclusion that could be shorter. The greatest problem is the shallow and unrealistic Hollywoodian approach, reducing the strength of the powerful drama, and I believe that this theme would be better explored by an independent director in a more realistic environment. The teenager Sofia Vassilieva has an awesome performance and Cameron Diaz is also great in the role of a mother that becomes obsessed to save her daughter and forgets her family. My vote is seven.