In Thailand, John Rambo joins a group of mercenaries to venture into wartorn Burma, and rescue a group of Christian aid workers who were kidnapped by the ruthless local infantry unit.

John J. Rambo is a former United States Special Forces soldier who fought in Vietnam and won the Congressional Medal of Honor, but his time in Vietnam still haunts him. As he came to Hope, Washington to visit a friend, he was guided out of town by the Sheriff William Teasel who insults Rambo, but what Teasel does not know that his insult angered Rambo to the point where Rambo became violent and was arrested, as he was at the county jail being cleaned, he escapes and goes on a rampage through the forest to try to escape from the sheriffs who want to kill him. Then, as Rambos commanding officer, Colonel Samuel Trautman tries to save both the Sheriffs department and Rambo before the situation gets out of hand.

Former Green Beret John Rambo is serving time in a federal prison. When the US military hears of American soldiers missing in action from the Vietnam war possibly still being alive and held captive, Colonel Trautman is authorized to send Rambo in to rescue them. For Rambo, this is what he would do best. If only the pencil-pushers would stop getting in his way.