A National Geographic film crew is taken hostage by an insane hunter, who takes them along on his quest to capture the worlds largest - and deadliest - snake.

Picking up immediately where Anaconda 3 left off, herpetologist Amanda Hayes finally learns her employer Murdoch s true colors when he hires a doctor to harvest a fresh supply of blood orchids to experiment with the regenerative nectar on a baby snake in order to seek treatment for his own terminal illness.[/center]

A National Geographic crew heads down the Amazon in a jungle boat to make a documentary on a long-lost tribe of natives. En route, they rescue a hunter from his sinking boat and take him on board. After the ships captain is attacked by a poisonous insect and goes comatose, the hunter commandeers the boat, takes the crew hostage, and drags them along on his insane quest to capture a giant anaconda.

When a documentary crew traveling through the Amazon jungle, picks up a stranded man, they are unaware of the trouble that will occur. This stranger s hobby is to capture the giant Anaconda snake, and plans to continue targeting it on their boat, by any means necessary.

When a documentary crew traveling through the Amazon jungle, picks up a stranded man, they are unaware of the trouble that will occur. This stranger s hobby is to capture the giant Anaconda snake, and plans to continue targeting it on their boat, by any means necessary.