Chosen for their ability to kill without conscience, a group of killers, some trained and some who are not, must endeavour the alien race of predators that have set out to target them as prey. Dropped into the vast jungle of a distant world, these human predators must learn just who, or what, they are up against, and that their ability, knowledge and wits are tested to the limits in the battle of survival of kill or be killed.

High above the arctic circle, on a remote Canadian island, a hunter shoots what he believes is a polar bear. He is mistaken. His Inuit guide has never seen an animal like this before. The killing unleashes an investigation by the Canadian authorities. But no-one can tell exactly what he has shot.

In Aliens vs. Predator players will have the chance to take the role of the three infamous species; the Colonial Marine, the Predator and the Alien. Each of the three species has its very own distinct story-driven single-player campaign mode that interweaves with the campaigns of the other two species.

Dutch and a small group of commandos and sent by the CIA to a Central American Jungle, to rescue capture airmen from Guerillas. But it's not the armed terrorists which are the problem. Something hidden in the jungle, something invisible to the naked eye, something not of this earth is the problem. As Dutch and his men had back to transport, they are slowly targeted one by one.