A group of people find themselves trapped in the backwoods of West Virginia, fighting for their lives against a group of vicious and horribly disfigured inbred cannibals.

A small-time crime boss kills a drug dealer without realizing that the drug dealer works for the biggest crime boss in the country.

Chris Flynn is driving his car for a job interview in another city. However, an accident with a trunk transporting chemical products blocks the highway and Chris looks for an alternative route through the mountains of West Virginia to accomplish his schedule. Due to a lack of attention, he crashes another car parked in the middle of the road with flat tires. Chris meets a group of five friends, who intended to camp in the forest, and they decide to leave the couple Francine and Evan on the place, while Chris, Jessie, Carly and her fiance Scott tries to find some help. They find a weird cabin in the middle of nowhere, where three violent cannibalistic mountain men with the appearance of monsters live. The two couples try to escape from the mountain men while chased by them.

While rafting in the Bluefish River area, four college kids are attacked by the mutant cannibal hillbilly Three Finger. Only the teenager Alex succeeds in escaping running through the woods. Meanwhile, a group of dangerous criminals are transported from the West Virginia Grafton Penitentiary in a custody bus escorted by three security guards through the backwoods. When they park in a rest stop in a police station, Sheriff Carver is informed about the missing teenagers.